Manchester United need to return to winning ways to push for Champions League qualification, on the other hand, Manchester City need a win to maintain their lead over Liverpool in the title race.
As far as the team news is concerned, reports indicate that Cristiano Ronaldo is absent and could miss the derby (MEN).
Ralf Rangnick has confirmed that Edinson Cavani is available but he would likely start from the bench for the Red Devils.
In such a scenario, we can expect Marcus Rashford to start as the main center forward up-front and the likes of Elanga and Sancho could feature in the wide attacking positions.
The likes of Brazilian international, Fred, could start with record signing, Paul Pogba, in the central midfield and in front of them, Bruno Fernandes must feature.
In the back-line, skipper Harry Maguire would likely return to partner Varane in the central defense in front of David De Gea.
On the other hand, Luke Shaw and Aaron Wan-Bissaka may start in the fullback positions. Here is how Man Utd could line up vs Man City: