Liverpool defeated Manchester United with a combined score of 9-0 in the two fixtures last term and the Red Devils should have revenge on their minds.
However, after earning nothing from the opening two games, it will be a huge achievement to even get a point against the Reds, who are also looking for their first win.
As far as the team news is concerned, Erik ten Hag could make three changes to the squad that started in the last game vs Brentford.
Despite being absolutely poor in the goal, Spanish shot stopper, David De Gea, might retain his place in the starting XI.
In the backline, skipper Maguire should be ousted and in his place, four-time Champions League winner, Rapahael Varane must start with Lisandro Martinez in the central defense.
Dalot may feature in the right back role again, however, left back, Luke Shaw, could be replaced with new signing, Tyrell Malacia.
In the center of the park, Donny van de Beek may replace Brazilian international, Fred, to feature with Christian Eriksen in the central midfield.
Unfortunately, Ten Hag not have depth in the attacking third and we may see, Sancho, Fernandes and Ronaldo retain their starting positions, however, Anthony Elanga must replace Rashford, who has been average for a long time.
Here is how Man Utd could line up vs Liverpool (4-2-3-1): De Gea; Dalot, Varane, Martinez, Malacia; Eriksen, Van de Beek, Fernandes; Elanga, Sancho, Ronaldo.