Manchester United’s big-money summer signing, Jadon Sancho, has not been able to replicate his Dortmund form at Old Trafford and even in the last game, he had an average outing.
Therefore, the England international needs to be benched and in his place, young Elanga could return to start vs Southampton today.
The likes of Fernandes and Rashford might retain their starting positions in the attacking third but we can expect Cristiano Ronaldo to return in place of Edinson Cavani.
As far as the midfield is concerned, Fred is still out with the COVID-19 virus and Matic has a shin problem, so, the likes of Pogba and McTominay could start again.
Telles has returned to training but it will be too early to start him, hence, Shaw would likely feature in the LB role. Wan-Bissaka could replace Dalot in the RB role.
The likes of Varane and Maguire should start in the central defense again and Spanish international, David De Gea, could retain his place in the goal.
Here is Man Utd’s strongest possible 4-3-3 XI vs Southampton: